ea0032p67 | Adrenal Medulla | ECE2013
Zampetti Benedetta
, Rapizzi Elena
, Ercolino Tonino
, Fucci Rossella
, Felici Roberta
, Guasti Daniele
, Giache Valentino
, Bani Daniele
, Chiarugi Alberto
, Mannelli Massimo
Paragangliomas (PGLs) are rare neuroendocrine tumors. About 3040% of these tumors are mutated in different susceptibility genes, including those encoding the different subunits of the succinate dehydrogenase, a complex involved both in the tricarboxylic acid cycle and in the oxygen transport chain. The aim of this project was to investigate whether SDHB mutations may account for alterations in cell metabolism and functions. Since PGL cell lines are not available, we used...